Every webmaster knows that Google is the king of generic traffic. And this is very important to be on good place in Google. 

Google introduced new option for webmasters: Geographic targeting... It looks like a good news, because now you can target you site to specific location. But, there are  bad news, the sites with regional domains (.uk .us .dk) targeted on these countries by Google automatically. Does that means that now if your site targeted world-wide but historically hosted in some regional domain lost visitors? Currently we have no answer about this, but I think this can affect traffic of sites that are hosted on regional domains.

Bad in this new feature of webmaster tools that you can't change geographic targeting for site located on regional domain. You'll see the following message

"Your site's domain (.XX) is already associated with the country/region: XXXXX"

This info can be interesting for owners of regional domains. You can check it in Google Webmaster Tools

I've currently mentioned that one my site on regional domain affected by this change. And I'm thinking to move it smoothly to some .com .org or .net domain to be world wide. So, don't locate your new site on regional domain, better longer, but world-wide.